The venue hosts a variety of events, including live music performances, themed nights like "Weddy Weddy Wednesdays," and sports watch parties. Notably, they have featured artists such as Mic Inity and House of Stone. Afro 161 also offers a lively atmosphere for social gatherings and celebrations.​ They also serve grilled meats and signature items such as the "Afrotopia Burger," which has received praise for its taste and presentation.